Fire Station 33 was originally on Shelter Island in 1961. The Harbor department took over that building in 1965 and Station 33 moved to Rancho Bernardo. The station opened at its current location in December 1969. The community raised funds and worked with the city to help pay for an extensive remodel of the station, reopening in January 2010.
Fire Station 33 serves Rancho Bernardo and its surrounding areas. Engine 33's district is 25.44 square miles.